Makoto Tsuda Selected Research

Purinergic P2 Receptors (ADP Receptor)

11/2012	[Role of the glia in neuropathic pain caused by peripheral nerve injury].
11/2010	Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn.
1/2008	Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.
11/2007	P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain.
9/2007	[Neuropathic pain and ATP receptors in spinal microglia].
9/2007	Modification of neuropathic pain sensation through microglial ATP receptors.
5/2007	[A new mechanism of neuropathic pain through ATP receptors in spinal microglia].
1/2006	[The role of microglia and ATP receptors in a mechanism of neuropathic pain].
6/2005	ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors.
10/2004	[ATP receptors in pain sensation].

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Makoto Tsuda Research Topics

Disease

52	Neuralgia (Stump Neuralgia) 01/2022 - 02/2004
46	Pain (Aches) 01/2022 - 05/2002
37	Hyperalgesia 01/2022 - 08/2003
21	Hypersensitivity (Allergy) 01/2021 - 01/2004
21	Peripheral Nerve Injuries 01/2019 - 08/2003
20	Chronic Pain 01/2021 - 01/2004
5	Inflammation (Inflammations) 01/2016 - 11/2007
4	Neoplasms (Cancer) 07/2020 - 08/2014
3	Hypertension (High Blood Pressure) 12/2017 - 01/2016
3	Acute Pain 01/2016 - 08/2003
2	Contact Dermatitis (Eczema, Contact) 01/2021 - 01/2020
2	Peripheral Nervous System Diseases (PNS Diseases) 10/2019 - 08/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2017 - 06/2017
1	Pathologic Constriction (Stenosis) 10/2020
1	Spinal Cord Compression 10/2020
1	Neuroinflammatory Diseases 07/2020
1	Heart Failure 01/2020
1	Contracture 01/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2020
1	Breast Neoplasms (Breast Cancer) 10/2019
1	Astrocytoma (Pilocytic Astrocytoma) 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Infections 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019

Drug/Important Bio-Agent (IBA)

19	Adenosine Triphosphate (ATP)IBA 01/2021 - 05/2002
14	Purinergic P2 Receptors (ADP Receptor)IBA 11/2012 - 08/2003
12	Purinergic P2X4 ReceptorsIBA 01/2022 - 05/2006
11	Purinergic Receptors (Receptors, Purine)IBA 01/2021 - 02/2005
7	Analgesics (Analgesic Drugs)IBA 07/2021 - 04/2009
7	CytokinesIBA 01/2018 - 03/2007
6	p38 Mitogen-Activated Protein KinasesIBA 03/2007 - 01/2004
5	NucleotidesIBA 01/2021 - 06/2005
5	Proteins (Proteins, Gene)FDA Link 07/2020 - 07/2006
5	Pharmaceutical PreparationsIBA 10/2019 - 11/2010
5	CationsIBA 01/2018 - 05/2006
4	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2021 - 02/2015
4	Transcription Factors (Transcription Factor)IBA 01/2021 - 05/2014
4	ChemokinesIBA 01/2017 - 09/2011
4	Opioid Analgesics (Opioids)IBA 01/2017 - 04/2009
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 03/2007
4	SB 203580IBA 03/2007 - 01/2004
3	Monoclonal AntibodiesIBA 01/2022 - 03/2013
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 03/2007
3	Morphine (MS Contin)FDA LinkGeneric 01/2021 - 01/2017
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2020 - 01/2016
3	Capsaicin (Zostrix)FDA Link 11/2020 - 05/2002
3	Duloxetine Hydrochloride (Cymbalta)FDA Link 11/2020 - 01/2016
3	purinoceptor P2Y6IBA 01/2020 - 01/2016
3	Messenger RNA (mRNA)IBA 11/2018 - 07/2006
3	InterleukinsIBA 01/2018 - 03/2007
3	GTP-Binding Proteins (G-Protein)IBA 12/2017 - 01/2016
3	gamma-Aminobutyric Acid (GABA)IBA 12/2012 - 12/2005
3	Freund's AdjuvantIBA 08/2012 - 11/2007
3	Formaldehyde (Formol)FDA Link 07/2011 - 05/2002
3	Fibronectins (Fibronectin)IBA 04/2008 - 05/2006
2	UridineIBA 01/2020 - 12/2017
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2019 - 11/2018
2	AntibodiesIBA 01/2019 - 03/2007
2	AngiotensinsIBA 12/2017 - 01/2016
2	N,N''- 1,4- butanediylbis(N'- (3- isothiocyanatophenyl))thioureaIBA 12/2017 - 01/2016
2	Clopidogrel (Plavix)FDA Link 06/2017 - 05/2008
2	Phosphotransferases (Kinase)IBA 02/2015 - 01/2008
2	Minocycline (Cyclops)FDA LinkGeneric 09/2014 - 05/2009
2	Chemokine CCL3IBA 08/2014 - 06/2014
2	CC ChemokinesIBA 08/2014 - 06/2014
2	LigandsIBA 08/2014 - 06/2009
2	Cell Surface ReceptorsIBA 01/2013 - 11/2009
2	Gabapentin (Neurontin)FDA LinkGeneric 12/2012 - 11/2010
2	Adenosine (Adenocard)FDA LinkGeneric 09/2011 - 02/2004
2	src-Family KinasesIBA 07/2011 - 01/2008
2	Platelet Activating FactorIBA 01/2011 - 09/2007
2	cangrelorIBA 11/2010 - 05/2008
2	platelet activating factor receptorIBA 05/2010 - 09/2007
2	Phospholipases (Phospholipase)IBA 05/2010 - 11/2007
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2009 - 01/2008
2	Phospholipases A2 (Phospholipase A2)IBA 05/2009 - 11/2007
2	U 0126 (UO 126)IBA 03/2008 - 09/2007
2	Protein Kinases (Protein Kinase)IBA 03/2008 - 09/2007
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2007 - 12/2005
2	OligodeoxyribonucleotidesIBA 01/2004 - 08/2003
1	preproenkephalinIBA 01/2022
1	Insulin (Novolin)FDA Link 01/2022
1	cilnidipineIBA 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	Neuropeptide YIBA 01/2021
1	erythromycin propionate-N-acetylcysteinateIBA 07/2020
1	Adrenergic Receptors (Adrenergic Receptor)IBA 07/2020
1	CpCpIBA 01/2020
1	AcetoneIBA 01/2020
1	Lipocalin-2IBA 01/2020
1	Small Molecule LibrariesIBA 10/2019
1	Fulvestrant (Faslodex)FDA Link 10/2019
1	Small Interfering RNA (siRNA)IBA 01/2019

Therapy/Procedure

5	Therapeutics 11/2016 - 08/2003
4	Drug Therapy (Chemotherapy) 10/2019 - 11/2010
3	Oral Administration 01/2016 - 05/2008
3	Spinal Injections 06/2014 - 05/2006
2	Ligation 01/2022 - 11/2010
1	Nerve Block (Nerve Blocks) 01/2022
1	Transcranial Direct Current Stimulation 01/2022